Thymosin Alpha-1 Reconstitution

How to reconstitute Thymosin Alpha-1

1. Swab the rubber stopper of the Thymosin Alpha-1 vial and the sterile water for injection vial with an alcohol wipe.
2. Draw 1 ml of sterile water for injection into a syringe.
3. Inject it slowly down the inside wall of the Thymosin Alpha-1 vial, not directly onto the powder.
4. Swirl gently until the powder fully dissolves. Do not shake. Shaking can damage the peptide.
5. Reconstitute with 1.0 ml of Sterile Water for Injection immediately before use, giving 1.6 mg/ml.

Thymosin Alpha-1 concentration by water volume

Thymosin Alpha-1 is commonly supplied in 1.6 mg vials. The concentration depends only on how much bacteriostatic water you add. More water lowers the concentration and makes small doses easier to measure.

Thymosin Alpha-1 units to draw

At 1,600 mcg/ml (a 1.6 mg vial in 1 ml of bacteriostatic water), here is the draw for doses across the range Thymosin Alpha-1 is typically used at. Change any number in the calculator above for your own vial.

Thymosin Alpha-1 dosing

In its approved hepatitis B use, Zadaxin is commonly dosed at 1.6 mg subcutaneously twice weekly, and other indications use different schedules. That is prescription dosing set in approved markets, not a validated self-administration regimen, so treat figures outside a clinical setting with corresponding caution. Enter your own vial size, water volume, and target dose in the calculator above to convert any Thymosin Alpha-1 protocol into exact insulin-syringe units. For the full profile, see the Thymosin Alpha-1 compound page.

Storing reconstituted Thymosin Alpha-1

Reconstitute with 1.0 ml of Sterile Water for Injection immediately before use, giving 1.6 mg/ml. The label directs immediate use rather than multi-dose storage. Reconstituted solution has been reported stable for 2 to 7 days at 4 degrees C, but that is not what the label instructs. Protect from light and do not freeze.

Not approved in the United States. Thymalfasin (Zadaxin) is approved in roughly 30 other countries for chronic hepatitis B and C; in the US it has only held orphan-drug and investigational status. The labelled dose is a single fixed 1.6 mg (900 mcg/m2) twice weekly with no titration schedule, which is why one dose row is shown rather than a ladder. The diluent is sterile water, not bacteriostatic water. Research-grade 5 mg and 10 mg vials sold outside the pharmaceutical supply chain are not the labelled product.

The dose range above comes from approved prescribing information for Thymosin Alpha-1.

The math

• Concentration (mcg/ml) = vial size in mg × 1,000 ÷ bacteriostatic water in ml.
• Volume for your dose (ml) = dose in mcg ÷ concentration.
• Units to draw = volume in ml × 100 on a U-100 insulin syringe.

Prefer a full workspace? The peptide dosage & reconstitution calculator adds blend, converter, half-life, and titration tools.

Thymosin Alpha-1 reconstitution FAQ

References

• https://www.rxlist.com/zadaxin-drug.htm
• https://registrasiobat.pom.go.id/files/assesment-reports/01751602483.pdf