Sermorelin Reconstitution

How to reconstitute Sermorelin

1. Swab the rubber stopper of the Sermorelin vial and the 0.9% sodium chloride injection vial with an alcohol wipe.
2. Draw 2 ml of 0.9% sodium chloride injection into a syringe.
3. Inject it slowly down the inside wall of the Sermorelin vial, not directly onto the powder.
4. Swirl gently until the powder fully dissolves. Do not shake. Shaking can damage the peptide.
5. Keep unreconstituted vials refrigerated at 2 to 8 degrees C.

Sermorelin concentration by water volume

Sermorelin is commonly supplied in 0.5 mg vials. The concentration depends only on how much bacteriostatic water you add. More water lowers the concentration and makes small doses easier to measure.

Sermorelin units to draw

At 250 mcg/ml (a 0.5 mg vial in 2 ml of bacteriostatic water), here is the draw for doses across the range Sermorelin is typically used at. Change any number in the calculator above for your own vial.

Sermorelin dosing

In anti-aging and wellness clinics, sermorelin is commonly prescribed at roughly 200 to 300 mcg by subcutaneous injection at night, timed to match the body's natural overnight GH pulse. This is off-label prescribing through compounding pharmacies rather than an FDA-approved regimen, so specifics vary by provider. Enter your own vial size, water volume, and target dose in the calculator above to convert any Sermorelin protocol into exact insulin-syringe units. For the full profile, see the Sermorelin compound page.

Storing reconstituted Sermorelin

Keep unreconstituted vials refrigerated at 2 to 8 degrees C. The former label specified 2 ml of Sodium Chloride Injection USP supplied in the kit, not bacteriostatic water, giving a solution at pH 5.0 to 5.5. Discard if cloudy or if particulates appear. The original label did not publish an extended in-use window.

The labelled dose was 0.2 to 0.3 mcg/kg once daily at bedtime, roughly 15 to 20 mcg for a 70 kg adult. Compounding pharmacies today market 200 to 500 mcg per dose, more than ten times the labelled range, with no label support. Geref was withdrawn from the US market in 2008, so no current FDA label governs sermorelin and vial size, diluent, and concentration vary by pharmacy.

The dose range above comes from approved prescribing information for Sermorelin.

The math

• Concentration (mcg/ml) = vial size in mg × 1,000 ÷ bacteriostatic water in ml.
• Volume for your dose (ml) = dose in mcg ÷ concentration.
• Units to draw = volume in ml × 100 on a U-100 insulin syringe.

Prefer a full workspace? The peptide dosage & reconstitution calculator adds blend, converter, half-life, and titration tools.

Sermorelin reconstitution FAQ

References

• https://www.rxlist.com/sermorelin-acetate-drug.htm
• https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=019863